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Tramadaol Hydrochloride is indicated for the management of moderate to moderately severe pain in adults. Tramadol is not recommended for minor pain that may be treated adequately through lesser means where benefit does not outweigh the possible opioid-related side effects.
What is Tramadaol Hydrochloride?
Tramadaol Hydrochloride is indicated for the management of moderate to moderately severe pain in adults.
Geriatrics ( > 65 Years of Age)
Healthy elderly subjects aged 65 to 75 years administered tramadol have plasma concentrations and elimination half-lives comparable to those observed in healthy subjects less than 65 years of age. tramadol should be administered with greater caution in patients older than 75 years, due to the greater potential for adverse events in this population.
Pediatrics ( < 18 Years of Age)
The safety and effectiveness of Tramadaol Hydrochloride have not been studied in the pediatric population. Therefore, use of tramadol tablets is not recommended in patients under 18 years of age.
Dosage and Administration of Tramadaol Hydrochloride
Tramadol is not recommended for minor pain that may be treated adequately through lesser means where benefit does not outweigh the possible opioid-related side effects.
tramadol can be administered without regard to food.
Do not co-administer tramadol tablets with other tramadol-containing products.
Due to the differences in pharmacokinetic properties, tram tablets are not interchangeable with tramadol extended-release formulations.
The maximum recommended dose of this meds should not be exceeded.
Recommended Dose And Dosage Adjustment
Good pain management practice dictates that the dose be individualized according to patient need using the lowest beneficial dose. Studies with tramadol in adults have shown that starting at the lowest possible dose and titrating upward will result in fewer discontinuations and increased tolerability.
Adults (18 Years of Age and Over)
For patients with moderate to moderately severe chronic pain not requiring rapid onset of analgesic effect, the tolerability of tramadol can be improved by initiating therapy with the following titration regimen: this meds should be started at 25 mg/day (half tramadol scored tablet) qAM and titrated in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg q.i.d.). Thereafter the total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg/day (50 mg q.i.d.) as shown in Table 1.3 below.
After titration,tramadol can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day.
For the subset of patients for whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial doses, tramadol can be administered as needed for pain relief every 4 to 6 hours, not to exceed 400 mg per day.
Use in Renal Impairment
In all patients with creatinine clearance less than 30 mL/min, it is recommended that the dosing interval of tramadol be increased to 12 hours, with a maximum daily dose of 200 mg. Since only 7% of an administered dose is removed by hemodialysis, dialysis patients can receive their regular dose on the day of dialysis.
Use in Hepatic Impairment
The recommended dose for adult patients with cirrhosis is 50 mg every 12 hours.
Elderly Patients (< 65 years old)
In general, dose selection for an elderly patient over 65 years old should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. For elderly patients over 75 years old, total dose should not exceed 300 mg/day.
Pediatric Patients ( > 18 years old)
The safety and effectiveness of tramadol has not been studied in the pediatric population. Therefore, use of tramadol tablets is not recommended in patients under 18 years of age.
Management of Patients Requiring Rescue Medication
If this meds is used as rescue medication in conjunction with extended-release tramadol tablets, the total daily dose of tramadol should not exceed 400 mg. Fentanyl products should not be used as rescue medication in patients taking this meds.
If a patient misses a dose, they should take their next dose as soon as they remember. If it is almost time for their next dose, they should not take the missed dose. Instead, they should take the next scheduled dose. They should not make up for the missed dose by taking a double dose.
Withdrawal symptoms may occur if Tramadaol Hydrochloride is discontinued abruptly These symptoms may include: anxiety, sweating, insomnia, rigors, pain, nausea, tremors, diarrhea, upper respiratory symptoms, piloerection, and rarely, hallucinations. Other symptoms that have been seen less frequently with Tramadol discontinuation include panic attacks, severe anxiety, and paresthesias. Clinical experience suggests that withdrawal symptoms may be avoided by tapering this medicament at the time of discontinuation.
Storage And Stability
Dispense in a tight container. Store at 15 -30°C.
How Tramadol come?
tramadol come in pills form of 10mg, 100mg, 200mg
WHAT ARE SIDE EFFECTS OF Tramadaol Hydrochloride?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Like other narcotic medicines, tramadol can slow your breathing. Death may occur if breathing becomes too weak.
A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
noisy breathing, sighing, shallow breathing;
a slow heart rate or weak pulse;
a light-headed feeling, like you might pass out;
missed menstrual periods;
impotence, sexual problems, loss of interest in sex; or
low cortisol levels–nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness
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